Journal article
Association between hypermethylation of DNA repetitive elements in white blood cell DNA and early-onset colorectal cancer
RJ Walters, EJ Williamson, DR English, JP Young, C Rosty, M Clendenning, MD Walsh, S Parry, DJ Ahnen, JA Baron, AK Win, GG Giles, JL Hopper, MA Jenkins, DD Buchanan
Epigenetics | TAYLOR & FRANCIS INC | Published : 2013
DOI: 10.4161/epi.25178
Abstract
Changes in the methylation levels of DNA from white blood cells (WBCs) are putatively associated with an elevated risk for several cancers. The aim of this study was to investigate the association between colorectal cancer (CRC) and the methylation status of three DNA repetitive elements in DNA from peripheral blood. WBC DNA from 539 CRC cases diagnosed before 60 years of age and 242 sex and age frequency-matched healthy controls from the Australasian Colorectal Cancer Family Registry were assessed for methylation across DNA repetitive elements Alu, LINE-1 and Sat2 using MethyLight. The percentage of methylated reference (PMR) of cases and controls was calculated for each marker. Odds ratios..
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Grants
Awarded by National Institutes of Health
Funding Acknowledgements
This work was supported by NHMRC project grant 1025799 and by the National Cancer Institute at the National Institutes of Health (RFA #CA-95-011) and through cooperative agreements with members of the Colon Cancer Family Registry and Principal Investigators of Australasian Colorectal Cancer Family Registry (U01 CA097735). CR is a Jass Pathology Fellow. MAJ is a NHMRC Senior Research Fellow and JLH is a NHMRC Australia Fellow.